10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 2 2016 (April - June) The main determinant of empiric treatment of urinary tract infections (UTI) is antibiotic sensitivity patterns of uropathogens in a population. The patterns of resistance among uropathogensin tertiary care hospital in South India can help establish local guidelines on treatment of UTI. A retrospective observational study was conducted at Kasturba Hospital, Manipal, from 1 lessThan sup greaterThan st lessThan /sup greaterThan Jan 2012 to 31 lessThan sup greaterThan st lessThan /sup greaterThan Dec 2012. The case records of 500 patients of either sex who were admitted to Kasturba Hospital, Manipal with diagnosis of UTI were studied. Sensitivity testing was done in each isolate. lessThan i greaterThan E.coli lessThan /i greaterThan comprised 64%; lessThan i greaterThan Klebsiella lessThan /i greaterThan 16%; lessThan i greaterThan Proteus lessThan /i greaterThan 3.7%; lessThan i greaterThan Pseudomonas lessThan /i greaterThan 6.15%; lessThan i greaterThan Staphylococcus lessThan /i greaterThan 2.8%; and lessThan i greaterThan Enterococcus lessThan /i greaterThan 4.92% of the isolates. Extended-spectrum beta-lactamase (ESBL) producers among lessThan i greaterThan E coli lessThan /i greaterThan , lessThan i greaterThan Klebsiella lessThan /i greaterThan and lessThan i greaterThan Proteus lessThan /i greaterThan were 63.41%, 53.84% and 33.33% respectively. lessThan i greaterThan E.coli lessThan /i greaterThan was highly resistant to amoxicillin-clavulanate (67.8%), and ciprofloxacin (67%) whereas it was least resistant to imipenem (1%), cefoperazone-sulbactam (3.9%) and amikacin (9.8%). lessThan i greaterThan Klebsiella lessThan /i greaterThan was highly resistant to ciprofloxacin (69.2%) whereas it was least resistant to imipenem (0%) and cefoperazone-sulbactam (3.2%). lessThan i greaterThan Proteus lessThan /i greaterThan was highly resistant to amoxicillin-clavulanate (67.3%) and ceftriaxone (66.7%), whereas it was least resistant to cefoperazone-sulbactam (0%), imipenem (12.5%), amikacin (16.7%) and netilmicin (16.7%). High prevalence of extended spectrum beta lactamase (ESBL) producers among uropathogens were seen in our study. Moreover, alarming rate of resistance to ampicillin, amoxicillin-clavulanate and ciprofloxacin should prevent the use of these commonly used antibiotics for empiric treatment of UTI. PRATIK PATEL, KL BAIRY AND MOHAN AMBERKAR UTI, antibiotic resistance, E. Coli, ESBL 18-23