International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 7 Issue 2
2016 (April - June)
ANTI-DIABETIC ACTIVITY OF METHANOLIC EXTRACT OF MEDICINAL PLANT RHODIOLA ROSEA L. RHIZOMES
lessThan i greaterThan Rhodiola rosea L. lessThan /i greaterThan (Crassulaceae) have been used as traditional medicines to increase physical endurance, work productivity, longevity and resistance to high altitude sickness, fatigue, depression, anaemia, impotence, gastrointestinal ailments, infections, and nervous system disorders in Russia, Scandinavia, and other countries. The objective of the study was to evaluate the anti-Diabetic activities from the methanolic extract of the rhizomes of lessThan i greaterThan Rhodiola rosea lessThan /i greaterThan . Crude methanolic extract of the herb lessThan i greaterThan Rhodiola rosea lessThan /i greaterThan were prepared and analyzed for its pharmacological activity. Swiss albino mice are used for the study. For the pharmacological tests, the extract of lessThan i greaterThan Rhodiola rosea lessThan /i greaterThan was dissolved in 0.1% Na-CMC in normal saline solution to prepare 50 mg/kg and 200 mg/kg concentrations. Diabetes mellitus was induced with Streptozotocin injection. Evaluation of body weight, estimation of serum lipid profile and estimation of biochemical parameters and total proteins were done. The diabetic groups treated with lessThan i greaterThan Rhodiola rosea lessThan /i greaterThan were compared with standard glibenclamide. The treatment with lessThan i greaterThan Rhodiola rosea lessThan /i greaterThan extract at doses of 50 and 200 mg/kg by orally continue for 21 days significantly normalized elevated blood glucose level, body weight and restored serum and liver biochemical parameters towards normal values in lessThan i greaterThan Rhodiola rosea lessThan /i greaterThan treated group when compared to diabetic control group. These findings point out the promising effect of lessThan i greaterThan Rhodiola rosea L lessThan /i greaterThan . rhizomes as a useful anti-diabetic agent in diabetic complications.
AVIJIT CHATTERJEE, BISWARUP SEN, MONALISA SENGUPTA, SHARMILY CHAKRABORTY AND PROF.(DR.)TAPAN KUMAR CHATTERJEE
Anti-diabetic activity, streptozotocin induced diabetis, methanolic extract, Rhodiola rosea.
200-209