10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 3 2016 (July - September) Zinc metallopeptidase is a promising target for drug intervention and its inhibitors are useful in antihypertensive activity. QSAR (2D and 3D) studies were performed on a series of Benzimidazole derivatives using (VLifeMDS4.2). QSAR study performed on 35 analogues of which 26 were used in the training set and the rest 9 is considered for the test set. Multiple linear regression (MLR) methodology with stepwise (sw) forward- backward variable selection method was used for building the QSAR models. The results of the 2D-QSAR models were further compared with 3D-QSAR models generated by manual method. The statistical significant model (r2=0. 7782; F test=25. 735; q2=0. 5576; q2se=0. 6544; pred_r2=0. 5975; pred_r2 se=1. 0889) were developed using molecular design suite (VLifeMDS4. 2) these investigating the substitutional requirements for the favourable anti-hypertensive activity. 1FNO ligands are used for docking in auto dock software. These biological active docking compounds are used to treat hypertension. K.RAJAMATHI, M.KALIDASAN, C. N. HEMALATHA M.VIJEY AANANDHI Benzimidazole derivatives, QSAR, Antihypertensive activity, 1FNO, VLifeMDS4. 2 208-225