10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 1 2011 (January - March) A simple, specific, accurate and precise RP-HPLC method was developed and validated for the determination of escitalopram oxalate in tablet dosage forms. A hypersil BDS C8, 5µ column having 250x4.6mm internal diameter in isocratic mode with mobile phase containing methanol: disodium hydrogen phosphate: acetonitrile (28:44:28v/v, pH 7.0±0.05) was used. The flow rate was 1.5ml/min and effluents were monitored at 226nm. The retention time of escitalopram oxalate was 8.45 min. The linearity range is 250-1500µg/ml with coefficient of correlation 0.9999. The method was validated in terms of accuracy, precision, repeatability. The percentage recovery for escitalopram oxalate was found to be 99.0%. The proposed method was successfully applied for quantitative determination of escitalopram oxalate in single dosage form for routine analysis.  A.Suneetha,B.Syama Sundar Escitalopram oxalate; anti-depressant; HPLC; validation. 140-146