10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 4 2016 (October - December) Quinoline derivatives possess a wide spectrum of antibacterial activity like antiseptic, analgesic, trypanocidal, germicidal, amoebicidal, antitubercular, anthelmintic and pyroplasmosis. Many quinoline derivatives possess antifungal effects. Realizing the medicinal importance of azo compounds and quinoline derivatives, it was considered worthwhile to incorporate these two moieties The work of synthesizing the mono azo dyes like 2-phenyl-4-hydroxy-6,7 substituted quinoline derivatives was especially undertaken to ascertain that such compounds could augment antibacterial activity. The synthesized compounds were tested for their antibacterial activity using Disc Diffusion Technique against lessThan i greaterThan Escherichia coli, Salmonella paratyphi B, Bacillus subtilis, lessThan /i greaterThan and lessThan i greaterThan staphylococcus aureus. lessThan /i greaterThan Different compounds of the parent substitute exhibited different results. FARIDA P. MINOCHEHERHOMJI AND KIRTIDA K. VAIDYA Antibacterial activity, Quinoline derivatives, Disc diffusion method, Therapeutic use. 412-415