10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 4 2016 (October - December) lessThan i greaterThan Phyllanthus emblica (syn. Emblica officinalis lessThan /i greaterThan ) or amla, is supposed to rejuvenate all the organ systems of the body, provide strength and wellness. It keeps us away from all the diseases by boosting our immune system. Besides, lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan  plant is reported to possess many pharmacological and clinical properties.Objective: To evaluate the anti- diabetic activity of commercially available extracts lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan on high fat diet and low dose streptozocin induced diabetic rats.Materials and Methods: Diabetes was induced in albino rats using streptozocin 35 mg/kg i.p after giving high fat diet for 2 weeks. Animals with fasting blood glucose (FBG) above 200 mg/dl one week after injecting streptozocin were randomly divided into four groups of six rats each. Group 1- Diabetic rats, received only the distilled water (control),Group 2 - Diabetic rats, received lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan crude extract (200 mg/kg/day)– lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan Low dose (PEL), Group 3– Diabetic rats, received lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan crude extract (400 mg/kg/day) – lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan High dose (PEH), Group 4– Diabetic rats, received Glibenclamide (0.6 mg/kg/day) - Standard (S). All the animals received the respective drugs for six weeks. FBG was measured every 2 weeks till the end of sixth weeks by glucose-oxidase method.Results: Commercially available extracts lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan showed significant fall in fasting blood glucose (P lessThan 0.001) from second week onwards in comparison to diabetic control group.Conclusion: The results suggest that commercially available extracts lessThan i greaterThan Phyllanthus emblica lessThan /i greaterThan have significant hypoglycemic activity in diabetic model. NISHANT PATHAK, GYANENDRA KUMAR AND RAKESH CHANDRA CHAURASIA Diabetes Mellitus, Emblica Officinalis, Fasting Blood Glucose, Madhumeha, Indian Gooseberry, Maharog 139-145