10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 4 2016 (October - December) lessThan i greaterThan Trichosanthes dioica lessThan /i greaterThan seeds are mentioned in various traditional texts as a drug used for vermicidal anthelmintic, insecticidal, sedative, diuretic, demulcent, and expectorant purpose ethnopharmacologically. Objective of the present study was investigation of anthelmintic activity of different extracts of lessThan i greaterThan Trichosanthes lessThan /i greaterThan lessThan i greaterThan dioica lessThan /i greaterThan seeds. Annelids, lessThan i greaterThan Pheretima posthuma lessThan /i greaterThan and nematodes, lessThan i greaterThan Ascaridia galli lessThan /i greaterThan were used to carry out experiments for anthelmintic activity. Piperazine citrate was used as a standard. Time required for paralysis and death (lethal time) of worms were noted for each sample of lessThan i greaterThan T. dioica lessThan /i greaterThan extracts and standard. The results demonstrated that treatment with  lessThan i greaterThan T. dioica lessThan /i greaterThan seeds extract significantly ( lessThan i greaterThan P lessThan /i greaterThan lessThan 0.05- lessThan i greaterThan P lessThan /i greaterThan lessThan 0.01) paralyzed and killed both of the worms, lessThan i greaterThan A. galli lessThan /i greaterThan and earthworms. The activity was found to be increased with dose. Ethanol and ethyl acetate extracts activity at 60 mg/ml concentration were comparable to the well known anthelmintic agent Piperazine citrate (10 mg/ml). In conclusion, the use of the seeds of lessThan i greaterThan T. dioica lessThan /i greaterThan as an anthelmintic has been confirmed and further studies are suggested to isolate the active principles responsible for the activity. NITIN KUMAR AND ANURAG Trichosanthes dioica, Parwal, Anthelmintic activity, Ascaridia galli, 229-232