10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 1 2011 (January - March) The aim of the present research work was to enhance the solubility of Carvedilol by solid dispersion method and to formulate a mouth dissolving tablet. Drugs are more frequently taken by oral administration. The solubility of Carvedilol enhanced with different ratios of PVP by the solvent evaporation method .In-vitro release profile of solid dispersion obtained in SGF with out enzymes and Ph 6.8 phosphate buffer indicate that 100% drug release found within 20 min. These solid dispersion were directly compressed into tablets using crospovidone, sodium starch glycol ate, croscarmellose sodium and polacrilin potassium in different concentrations as a superdisintgrants. The prepared tablets containing the solid dispersion of Carvedilol having sufficient strength of 2.5-4 kg/cm2. The disintegranted in the oral cavity with in 21 sec. contain crospovidone (5%) as super disintegrant.  Himmat Singh,Swatantra Ku. Mishra,Rakesh Varma,Sandeep Singh Parihar Carvedilol, PVP, Super Disintegrants, Mouth Dissolving Tablet. 232-239