10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 4 2016 (October - December) lessThan i greaterThan Millingtonia hortensis lessThan /i greaterThan is commonly found in southern Asia, Thailand and central India, which is used to treat many diseases. The present study is to evaluate the preventive effect of silver nanoparticles synthesized from lessThan i greaterThan Millingtonia hortensis lessThan /i greaterThan on isoproterenol induced cardiotoxicity in male lessThan i greaterThan Wistar lessThan /i greaterThan rats. Results indicated that the rats administered with silver nanoparticles synthesized from lessThan i greaterThan Millingtonia hortensis lessThan /i greaterThan showed a significant increase in the levels of enzymatic antioxidants SOD, CAT, GPX and GST and non- enzymatic antioxidants Vit-C, E and GSH. A decreased level of LPO was observed after treatment with silver nanoparticles. Flavonoids, phenols, glycosides and alkaloids are the important phyto constituents found in the plant extract. The study concluded that lessThan i greaterThan Millingtonia hortensis lessThan /i greaterThan enhanced the antioxidant status in isoproterenol induced cardiotoxicity in rats. R.SAVITHA AND U.SARASWATHI Millingtonia hortensis, cardiotoxicity, antioxidants, isoproterenol. 272-277