10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 1 2011 (January - March) Novel schiff and mannich bases of isatin derivatives were synthesized. The structures of these compounds were established by means of IR, 1H-NMR analysis. All the compounds were evaluated for analgesic and ulcerogenic activities. Most of the compounds shown significant analgesic activity and lesser ulcerogenic property, when compared with the standard drugs. lessThan br / greaterThan Ramachandran S.,Uma Maheswari V. Isatin, Schiff and Mannich bases, Analgesic, Ulcerogenic. 251-260