10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 1 2017 (January - March) Andrographis echioides ,otherwise called as false water willow is a medicinal plant which was used as the remedy for curing fever,headache,constipation etc.This plant is mainly found in countries like India and Srilanka. The above study involves evaluation of anti diabetic activity of ethanolic extract of lessThan i greaterThan Andrographis echioides lessThan /i greaterThan plant (gopuram Thaangi) using alpha glucosidase assay and alpha amylase assay. The collected whole plant material was extracted using ethanol solvent and was further concentrated under reduced pressure. This was subjected to an lessThan i greaterThan in vitro lessThan /i greaterThan alpha glucosidase and alpha amylase inhibition activity for anti diabetic effect whose absorbance was measured using spectrophotometery. Acarbose, an approved antidiabetic drug was used as a positive control. Alpha glucosidase inhibition activity of ethanolic extract of lessThan i greaterThan Andrographis echioides lessThan /i greaterThan was 75.7% with 50% inhibitory concentration (IC50) of 500 mcg/ml and that of Alpha amylase inhibition activity was 66.6% with IC50 of around 500 mcg/ml. Acarbose (reference) exhibited 94.6 % inhibition with IC50 of 250 mcg/ml. The assay results show that the " lessThan i greaterThan Andrographis echioides lessThan /i greaterThan " has inhibitory activity on alpha glucosidase enzyme and alpha amylase enzyme. The alpha glucosidase inhibition is more compared to alpha amylase inhibition but their antiglucosidase and antiamylase activity is less when compared to the control drug Acarbose. DR.ANITHA E,DR.PUNNAGAI K,DR.DARLING CHELLATHAI,DR.LATHA RANI.M Ethanolic, Alpha glucosidase, Alpha amylase, Acarbose, Andrographis Echioides 50-54