10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 1 2011 (January - March) A Series of Schiff's bases of 4(2-amino phenyl) morpholines (1-V) were synthesized compounds were confirmed by IR, 1HNMR and MASS spectrum. All the newly synthesized compounds have been screened for their in vitro antibacterial activities against S.aureus , S. epidermis, B. cereus, B. subtilis, Ps. aureus, Kl. pneumonia and E. coli and antifungal activities against A. niger and C. albicans. Their minimal inhibitory concentration (MIC) values ranged between 1-10 µg/ml. The screening data indicates that the compounds I to V have promising anti-bacterial activity and antifungal activity by disc diffusion method by measuring the zone of inhibition and the results were compared to standard drugs ciprofloxacin and ketoconazole respectively.  lessThan br / greaterThan Gnana Ruba Priya,Panneerselvam,Karikalan Synthesis, morpholines derivatives, Schiff base, Anti-bacterial activity 267-272