10.22376/ijpbs.2019.10.1.p1-12 Volume 7 Issue 4 2016 (October - December) The army worm lessThan i greaterThan Spodoptera litura lessThan /i greaterThan (Fabricius) is one of the most destructive polyphytophagus crop pests in Indian sub-continent. The present study aims to investigate the effect of three fungal pathogens lessThan i greaterThan Beauveria bassiana, Metarhizium anisopliae lessThan /i greaterThan and lessThan i greaterThan Verticillum lecanii lessThan /i greaterThan on the total protein content and also on detoxifying enzymes like Glutamic Pyruvic Transaminase (GPT), Glutamic Oxaloacetate Transaminase (GOT), Alkaline Phosphatase (ALP) and Acid Phosphatase (ACP) and Acetylcholine esterase (AChE). The 48 and 96 hrs post infected larvae were used for evaluation. Throughout the study there was significant changes in the level of protein, GPT, GOT, ALP, ACP and AchE indicate very high elevations in both lessThan i greaterThan Beauveria bassiana and Metarhizium anisopliae lessThan /i greaterThan treated larvae. Hence there is no significant elevation in lessThan i greaterThan Verticillum lecani lessThan /i greaterThan treated larvae. It is proved by the results that these fungal pathogens cause significant inhibition of metabolic enzymes. VIDHYA, D., P. RAJIV AND NALINI PADMANABHAN Beauveria bassiana, Metarhizium anisopliae, Verticillum lecanii, Spodoptera litura, GOT, GPT, ALP, ACP, AChE. 943-948