International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 8 Issue 1
2017 (January - March)
Assessment of the levels of some trace elements in polycystic ovary syndrome and the possible association With insulin resistance.
PCOS is a complex disorder that begins during puberty and affects reproductive-age women, known as functional ovarian hyperandrogenism. It is characterized by varied metabolic and endocrine abnormalities.Women with PCOS are known to be at increased risk for insulin resistance . We aimed to investigate the serum levels of essential trace elements Zinc, copper, magnesium, iron and cobalt in patients with polycystic ovary syndrome and its potential association with insulin resistance (IR).: this study was carried out in infertility department at Babylon hospital for maternity and children, Hilla, Iraq. The period of study from June 2015 to March 2016 : A total of 60 women (30 patients with PCOS and 30 healthy controls) were included in this study. Serum zinc, iron, copper, magnesium and cobalt levels were analyzed using spectrophotometric method. Fasting blood sugar FBS and insulin were measured and IR was expressed as HOMA: Patients with PCOS higher BMI than control group, the difference was statistically significant (p-value 0.003).Fasting insulin and HOMA values were significantly higher in women with PCOS than control group. Women with PCOS-IR had significantly higher fasting insulin and HOMA levels compared to women with PCOS with normal insulin resistance (PCOS-NI). There was no significant difference in fasting blood sugar between women with PCOS and control groups. Serum zinc, iron and copper levels were significantly higher, but serum magnesium and cobalt were lower in patients with PCOS compared with the healthy participant. conclusion 1. Fasting insulin and HOMA values were significantly higher in women with PCOS than control group 2. serum zinc, iron and copper were significantly higher in patients with PCOS than control group.3. Serum magnesium and cobalt were lower in patients with PCOS than control group.
MILAL M. AL-JEBORRY
Polycystic ovary syndrome , women, endocrine disorder , insulin resistance.
143-151