10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 1 2017 (January - March) The study was aimed to investigate the molecular mechanisms underlying triggering of apoptosis by quercetin using lessThan i greaterThan in silico lessThan /i greaterThan analysis. The mechanism of binding of quercetin with NF-kB and other apoptotic proteins like BCL lessThan sub greaterThan 2 lessThan /sub greaterThan and BCL lessThan sub greaterThan XL lessThan /sub greaterThan was analyzed lessThan i greaterThan in silico lessThan /i greaterThan using Schrodinger suite 2009.Quercetin was found to exhibit high-affinity binding resulting from greater intermolecular forces between the ligand and its receptor NF-kB (-0.281 Glide score and -6.172 Docking Score). Quercetin binds to NFкB very strongly with metallic coordination.It can act as a inhibitor of apoptosis inhibitor when compared to BCL lessThan sub greaterThan XL lessThan /sub greaterThan and BCL lessThan sub greaterThan 2. lessThan /sub greaterThan Quercetin down regulates the cell survival proliferative anti-apoptotic proteins thereby can prevent prostate cancer. To confirm this, in vitro study can be carried out with techniques like MTT Assay, Western blot, and polymerase chain reaction. RAJATHI.K AND S.SUJA Quercetin,NF-kB,TNF-α, Molecular interaction 463-469