10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 2 2017 (April - June) In the present work mucoadhesive gels of Tinidazole that adhere with gums for an extended time period were prepared and evaluated. Tinidazole (TZ) is an antibacterial drug used for treatment of Periodontitis. Different gel formulations were prepared using the bio adhesive polymers like carbopol 974, sodium alginate and sodium carboxy methyl cellulose. The other additives used are triethanolamine as an emulsifier and surfactant, glycerol as a means of improving smoothness, providing lubrication and as humectants, mannitol as the isotonic agent and methylparaben as a preservative. The physicochemical compatibility of the drug and the polymer was assessed by FTIR spectroscopy. The prepared gels were evaluated for various parameters like viscosity, pH, drug content, swelling index, spread ability and lessThan i greaterThan Ex- Vivo lessThan /i greaterThan drug permeation. Release of Tinidazole from the gels formulated by employing carbopol 974 extended the drug release up to 6hrs. So the formulations F lessThan sub greaterThan 7 lessThan /sub greaterThan , F lessThan sub greaterThan 8 lessThan /sub greaterThan , and F lessThan sub greaterThan 9 lessThan /sub greaterThan were found to be optimized formulae. S.GOUSIA BEGUM* AND Dr .M.SEKAR Tinadazole, Mucoadhesive Buccal gels, Periodontitis and Ex- Vivo drug permeation 48-55