10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 2 2017 (April - June) The leaves of lessThan i greaterThan Mangifera indica lessThan /i greaterThan and lessThan i greaterThan Piper betle lessThan /i greaterThan are known for their antioxidant and antimicrobial properties. In the present study, the phytochemical constituents of the leaves of lessThan i greaterThan Mangifera indica lessThan /i greaterThan and lessThan i greaterThan Piper betle lessThan /i greaterThan were analyzed and their antibacterial properties were tested against bacteria isolated from dental caries. lessThan i greaterThan Staphylococcus aureus lessThan /i greaterThan (ASDV5,6,7,12), lessThan i greaterThan Staphylococcus epidermidis lessThan /i greaterThan (ASDV 4, 10), lessThan i greaterThan Streptococcus mutans lessThan /i greaterThan (ASDV 2, 3, 9) were isolated on Mannitol salt agar and blood agar from caries tooth scum samples. All the isolates of lessThan i greaterThan S. aureus lessThan /i greaterThan , lessThan i greaterThan S. epidermidis lessThan /i greaterThan and lessThan i greaterThan Streptococcus mutans lessThan /i greaterThan were sensitive to Ciprofloxacin, Azithromycin, Tetracycline and resistant to Clotrimazole, Methicillin. Leaf extracts of lessThan i greaterThan Mangifera indica lessThan /i greaterThan and lessThan i greaterThan Piper betle lessThan /i greaterThan were prepared using various solvents and tested against the bacterial isolates. The phytochemical analysis revealed the presence of tannins, flavonoids, alkaloids, terpenoids, glycosides, carbohydratesˏ saponins and resins. The antibacterial activity of the leaf extract of lessThan i greaterThan M. indica lessThan /i greaterThan showed a zone of inhibition ranging from 10 to 20 mm at a concentration of 50, 100 µg whereas the antibacterial activity of the leaf extract of lessThan i greaterThan P. betle lessThan /i greaterThan showed a zone of inhibition ranging from 10 to 25mm at the same concentration against lessThan i greaterThan S. aureus lessThan /i greaterThan , lessThan i greaterThan S. epidermidis lessThan /i greaterThan and lessThan i greaterThan Streptococcus mutans lessThan /i greaterThan . The findings of the study indicate a propensity of these plants for drug development. DIVYALASHMI L AND ARUNA SHARMILI S Mangifera indica, Piper betle, Dental caries, Antibacterial activity, Drug Development 84-91