10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 2 2017 (April - June) With an objective to study the effect of high uric acid levels on insulin resistance, lessThan i greaterThan a total of 100 subjects were categorized into two groups (Group A and Group B) based on their serum uric acid levels lessThan /i greaterThan . They were investigated for fasting plasma glucose, insulin and HbA1c. HOMA-IR was calculated basing on plasma glucose and insulin. Fasting plasma glucose, insulin and HbA1c levels showed an increase in Group B subjects when compared to Group A. HOMA –IR which is the indicator for insulin resistance also showed an increase in Group B subjects when compared to Group A. This increase is statistically significant (p lessThan 0.001). The beneficial effect of uric acid as an antioxidant is challenged by its abnormal concentration in the serum. This may lead to prediabetes which, over a period of time, might progress to frank diabetes. Thus serum uric acid level can act as a warning signal for future onset of diabetes. D.LAKSHMI LALITHA, B.SREEHARI BABU, DSSK RAJU eNOS, HOMA-IR, prediabetes 200-204