10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 2 2017 (April - June) The misuse and overuse of antibiotics has led to the selection of new strains of bacteria that resist to antibiotics, a situation which is found in the case of lessThan i greaterThan Escherichia coli lessThan /i greaterThan strains. There are many types of lessThan i greaterThan E. coli lessThan /i greaterThan and most of them are harmless. But some stereotypes can cause food poisoning, bloody diarrhoea and gastrointestinal infections. lessThan i greaterThan E. coli lessThan /i greaterThan is the most common cause of urinary tract infections (UTIs) in humans and leading cause of enteric infections. Some of the strain can also cause kidney failure, which can lead to death. In this study we have evaluated the ability of lessThan i greaterThan E. coli lessThan /i greaterThan strains to resist antibiotics isolated from infections of the gastrointestinal system and diarrhoea. The objective of this study was to determine the sensitivity of lessThan i greaterThan E. coli lessThan /i greaterThan to antimicrobial drugs. A total of 285 strains of lessThan i greaterThan E. coli lessThan /i greaterThan were evaluated for their antibiotic resistant pattern against eight selected antibiotics. The antibiotic sensitivity test was performed using the disc diffusion method prepared according to the standards of the Clinical and Laboratory Standard Institute (CLSI). The results showed over 53.33% of the strains were resistant to ampicillin and 69.47% were resistant to Ciprofloxacin and most of the strains were sensitive to Chloromphenicol (92.98%), Amikacin (76.49%) and Nalidixic acid (70.53%). SIDDARTH.B.SURWONSE AND KELAMANI CHANDRAKANTH R Escherichia coli, Urinary Tract infections (UTI), Multi Drug Resistance (MDR), Minimal Inhibitory Concentration (MIC), Antibiotics. 479-483