10.22376/ijpbs.2019.10.1.p1-12 Volume 8 Issue 2 2017 (April - June) The fungi have an important role in the environment. They cause the infections when grow on human. There is urgent need to get a new therapeutics or remedies from nature to inhibit the growth of pathogenic fungi. In the present study, the chemical composition of lessThan i greaterThan Citrus lessThan /i greaterThan lessThan i greaterThan grandis lessThan /i greaterThan volatile oil and anti-dermatophytic activity was evaluated against isolated dermatophytic species. The Clear pale yellowish color with fresh and sweet aroma oil was extracted from the leaves of lessThan i greaterThan Citrus grandis lessThan /i greaterThan that revealed the presence of 39 volatile components. The oil has revealed excellent inhibition activity against test organisms with presence of Maximum Inhibition Zone of 14.33 mm for lessThan i greaterThan Microsporum gypsium lessThan /i greaterThan as well as 14 mm against lessThan i greaterThan T lessThan /i greaterThan lessThan i greaterThan richophyton lessThan /i greaterThan lessThan i greaterThan mentagrophytes lessThan /i greaterThan (KU578106) as compared to standard. The present study detailed to chemical composition of lessThan i greaterThan Citrus lessThan /i greaterThan lessThan i greaterThan grandis lessThan /i greaterThan volatile oil with the confirmative presence of phenol components. The data also prove the anti-dermatophytic potential against lessThan i greaterThan Microsporum lessThan /i greaterThan and lessThan i greaterThan Trichophyton lessThan /i greaterThan species. The data also represent the further requirements for to investigate the various pharmacological behaviors to its commercialization for the advantage of human beings. VISHNU SHARMA, ANIMA SHARMA AND RUCHI SETH Dermatophytes; Citrus grandis; Volatile; Hydro Distillation; MIC 149-155