10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 1 2011 (January - March) The important medicinal part of the ginger plant is rhizome. There are several chemical constitutes present in rhizome, in which [6]-Gingerol, [10]-Gingerol, Zerumbone and Shogaols inhibit Colon Cancer, among these [6]-Gingerol and [10]-Gingerol are very important. In the fresh ginger rhizome, the gingerols were identified as the major active components. Gingerol can remain in two form and this depends upon its structure (the position of the methoxy group) known as [6]-gingerol and [10]-Gingerol. The present review sought to conclude that the phytochemical (Gingerol) have the greater potency on treatment of the various lethal diseases such as colorectal cancer. There are various reports which give the details of mechanism about the inhibitory process of gingerol on colon cancer. Therefore, gingerol might be a new therapeutic agent for the better treatment of human colon cancer for that further research on gingerol is necessary.  Piyali Sarkar,Md Abdul Kabieo Mahmud,Sudarsan Sahu,Ajoy Kumar Ghosh Zingiber officinale, [6]-Gingerol, [10]-Gingerol, Colon Cancer, colorectal cancer, Leukotrine A4 hydrolase 816-827