10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 2 2018 (April-June) The widely used non-steroidal anti-inflammatory drugs (NSAIDs) are detected on the order of ng/L to g /L in the effluent of sewage treatment plants and river water. These pharmaceutical drugs are resistant to degradation. Therefore the powerful treatment process is needed for the degradation of pharmaceutical contaminants. The main objective of this study was to investigate the Electrochemical (EC) degradation of NSAIDs of Piroxicam (PCM) by using RuO lessThan sub greaterThan 2 lessThan /sub greaterThan / IrO lessThan sub greaterThan 2 lessThan /sub greaterThan / TaO lessThan sub greaterThan 2 lessThan /sub greaterThan coated Ti- mesh anodes. Cyclic voltammetric study of oxidation and reduction when we added to the 0.1M Na lessThan sub greaterThan 2 lessThan /sub greaterThan SO lessThan sub greaterThan 4 lessThan /sub greaterThan supporting electrolyte, the oxygen evolution reactions and hydrogen evolution reactions are observed at 0.8 and 0.5 V vs. Ag/AgCl (scan rate at 20 mV/s). These optimized results reveal that the EC oxidation on RuO2/TaO lessThan sub greaterThan 2 lessThan /sub greaterThan /IrO lessThan sub greaterThan 2 lessThan /sub greaterThan -TiO lessThan sub greaterThan 2 lessThan /sub greaterThan lessThan sub greaterThan lessThan /sub greaterThan electrode was totally irreversible. The degradation efficiency of PCM was further confirmed by UV-Spectra analysis. The effects of the oxidative potential, current density, initial concentration of PCM, electrolysis time, electrolyte concentration and initial pH evaluated. At the optimum conditions (current density = 5 mA/cm lessThan sup greaterThan 2 lessThan /sup greaterThan , initial concentration = 20 mg/L, pH = 5.4, and electrolyte concentration = 0.1M Na lessThan sub greaterThan 2 lessThan /sub greaterThan SO lessThan sub greaterThan 4 lessThan /sub greaterThan ), after 180 min, the removals of PCM concentration, chemical oxygen demand (COD) and total organic carbon (TOC) were about 99.9%, 71.6%, and 56.7%, respectively. The parameters, K value, half-life (t lessThan sub greaterThan 1/2 lessThan /sub greaterThan ) and R lessThan sup greaterThan 2 lessThan /sup greaterThan . The rate constant (k) values were calculated using linear regression. The PCM degradation reaction followed pseudo-first-order kinetics (R lessThan sup greaterThan 2 lessThan /sup greaterThan greaterThan 0.90). The results showed that the electrochemical oxidation, using RuO lessThan sub greaterThan 2 lessThan /sub greaterThan / IrO lessThan sub greaterThan 2 lessThan /sub greaterThan / TaO lessThan sub greaterThan 2 lessThan /sub greaterThan coated TiO lessThan sub greaterThan 2 lessThan /sub greaterThan - mesh anode as highly effective material for degradation of NSAIDs. GANESAN SIVARASAN AND LINGASSAMY ARUL PRAGASAN Piroxicam, Electrochemical degradation, mixed metal oxide, electrolysis, NSAID. 22-29