10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 2 2018 (April-June) To date, limited studies have been performed to investigate the frequency of lessThan i greaterThan ACE lessThan /i greaterThan I/D and lessThan i greaterThan ACTN3 lessThan /i greaterThan R577X polymorphisms in Malay population. Moreover, information on the association of these two polymorphisms with muscular performance, aerobic and Wingate anaerobic capacities in Malay physically active males are limited. Hence, the present study was designed to investigate the association of lessThan i greaterThan ACE lessThan /i greaterThan I/D and lessThan i greaterThan ACTN3 lessThan /i greaterThan R577X polymorphisms with muscular performance, aerobic and Wingate anaerobic capacities among Malay young males. Sixty six Malay males (physically active, n=33; physically non-active, n=33) were recruited. Participants' flexibility, hand grip strength, back and leg strength, standing long jump power, vertical jump power, lung functions, maximum oxygen uptake (VO lessThan sub greaterThan 2max lessThan /sub greaterThan ) measured via treadmill running test, Wingate anaerobic capacities were measured. Genotyping of lessThan i greaterThan ACE lessThan /i greaterThan I/D and lessThan i greaterThan ACTN3 lessThan /i greaterThan R577X polymorphisms were performed on genomic DNA of the participants. Among physically active participants, II and ID genotypes of the lessThan i greaterThan ACE lessThan /i greaterThan polymorphism were significantly associated with higher forced vital capacity and VO lessThan sub greaterThan 2max lessThan /sub greaterThan . Additionally, lessThan i greaterThan ACE lessThan /i greaterThan ID genotype was significantly associated with greater back and leg strength and peak power respectively. Physically active participants with lessThan i greaterThan ACTN3 lessThan /i greaterThan RR genotype exhibited significantly higher mean power and peak power as compared to those with XX genotype. These findings imply that lessThan i greaterThan ACE lessThan /i greaterThan II genotype to be associated with greater aerobic capacity. lessThan i greaterThan ACE lessThan /i greaterThan ID genotype were found not only to be associated with greater aerobic capacity, but also with greater muscular strength and anaerobic peak power. In addition, lessThan i greaterThan ACTN3 lessThan /i greaterThan RR genotype seems to be associated with greater anaerobic performance among Malay physically active young males. XIAO LI, FOONG KIEW OOI, SHING CHENG TAN, BIN ALWI ZILFALIL ACE, ACTN3, polymorphism, muscular strength, anaerobic capacity, aerobic capacity 87-98