10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 2 2018 (April-June) The aim of this study was to evaluate the susceptibility of Resilon to biodegradation by endodontically relevant bacteria like lessThan i greaterThan Enterococcus faecalis, Propionibacterium acnes, Actinomyces viscosus, Pseudomonas aeruginosa lessThan /i greaterThan and fungi like lessThan i greaterThan Candida albicans lessThan /i greaterThan which are commonly present in failed root canal treatment cases. Resilon pellets dissolved in chloroform to form an emulsion were subjected to disruption using ultrasonic disrupter. This sonication procedure resulted in the formation of nanodroplets. Serial dilutions of nanodroplets of Resilon lessThan b greaterThan lessThan /b greaterThan were done. Equal volume of Resilon emulsion and double strength Brain Heart Infusion Agar were mixed ,sterilized and distributed into petriplates. Endonditically related bacteria and fungi were inoculated onto culture media and zone of iinhibhition was observed after 24 and 48 hours of incubation, measured using a Computer Aided Design (CAD) software and the values were given in square cm. The values were subjected to statistical analysis using one way ANOVA followed by Post hoc test and paired test.All the test microorganisms included in the study showed significant amount of zone of clearance. lessThan b greaterThan lessThan /b greaterThan It lessThan b greaterThan lessThan /b greaterThan can be concluded that Resilon lessThan b greaterThan lessThan /b greaterThan undergoes biodegradation. Further studies should be carried out to test the biodegradability of Resilon bound to its sealer in an environment that mimics the root canal. DR. C. GANDHIMATHI, DR. LAVANYA THANGAVELU, DR. V. PRABHAKAR Resilon, Zone of clearance, Biodegradation. 133-138