10.22376/ijpbs.2019.10.1.p1-12 Volume 9 Issue 2 2018 (April-June) The present study deals with the cytotoxic property of various extracts of of lessThan i greaterThan Eleutherine bulbosa lessThan /i greaterThan bulbs.It was evaluated by a simple, low cost bioassay such as brine shrimp lethality assay. It was found that the crude ethyl acetate extract of the plant exhibited significant toxicity against the shrimp larvae (nauplii) when compared to that of potassium permanganate (positive control) and it is a good indicator of toxicity. The results suggested that crude ethyl acetate extract of lessThan i greaterThan E.bulbosa lessThan /i greaterThan bulb possesses significant cytotoxic activity. The LC lessThan sub greaterThan 50 lessThan /sub greaterThan value of crude ethyl acetate extract at 95% confidence limit is 6.276μg/ml – 8.073μg/ml. A proper chemical profiling of this extract is therefore warranted in order to find out the specific compound responsible for the bioactivity. RANI.V.S Eleutherine bulbosa, Brine shrimp, Cytotoxic, Potassium permanganate. 125-130