10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 1 2011 (January - March) Advanced oxidation protein product (AOPP) and protein carbonyl (PC) as protein oxidation products (PPP) and antioxidants such as reduced glutathione (GSH),total thiol (TT) and albumin levels were analyzed in 27 patients with diagnosed primary brain tumor and 25 normal healthy age and sex matched controls. Statistically significant increased (p-0.001) levels of AOPP and PC were noted; GSH and TT levels were increased (p-0.833) & (p-0.032) respectively with decreased albumin levels (p-0.629).Hence increased oxidative stress signified by increased PPP and altered antioxidant levels may have a role in etipathogenesis of primary brain tumor.  lessThan br / greaterThan AMARESHWARA M,GAYATRI M RAO,RAKESH M,RAMESH,SAMEER,SREEKANTHA Primary brain tumor, Protein oxidation products,Antioxidants. 582-587