10.22376/ijpbs.2019.10.1.p1-12 Volume 1 Issue 4 2010 (October - December) A simple, sensitive and rapid ionpair high performance liquid chromatographic methodwas developed for the estimation ceftriaxone sodium (CS) and tazobactum sodium (TS) in pharmaceutical dosage forms. LichrocartR100-RP18e5µm-C18 column was used with a mobile phase containing mixture of 0.012M tetra butyl ammonium hydroxide in 0.01M potassium dihydrogen phosphate : acetonitrile in the ratio of 70:30 v/v. The flow rate was 0.8ml/min and effluents were monitored at 220nm and eluted at 4.5 and 6.7 min for tazobactum sodium (TS) and ceftriaxone sodium (CS) respectively. Calibration curve was plotted with a range from 2 to 12 µg/ml (CS) and 0.26 to 1.56 (TS) µg/ml. The assay was validated for the parameters like accuracy, precision, robustness and syste m suitability parameters. The proposed method can be useful in the routine analysis for the determination of ceftriaxone sodium and tazobactum sodium in pharmaceutical dosage forms. M. Gandhimathi, M. Saravanakumar, T. K. Ravi Ceftriaxone sodium, tazobactum sodium,ion-pair HPLC, Pharmaceutical dosage forms 17-22