10.22376/ijpbs.2019.10.1.p1-12 Volume 10 Issue 3 2019 (July-September) Obesity, the chronic metabolic disorder resulting from the imbalance between energy intake and energy expenditure, the characteristics of it are, enlarged fat mass and elevated lipid concentration in blood. lessThan i greaterThan Aconitum Heterophyllum lessThan /i greaterThan is an indigenous medicinal plant of India and belongs to the family Ranunculaceae. lessThan i greaterThan A. Heterophyllum lessThan /i greaterThan is known to possess a number of therapeutic effects. For very ancient times, this plant has been used in some formulations in the traditional healing system of India. In the present study, the Anti-obesity activity of successive solvent extract by petroleum ether, chloroform and ethanol of lessThan i greaterThan A. heterophyllum are reported lessThan /i greaterThan . The ethanolic extract of lessThan i greaterThan A. heterophyllum lessThan /i greaterThan was orally administered in high-fat high cholesterol diet (HFHCD) obese rats for about 12-14 weeks. After four weeks of treatment, blood samples were collected for the estimation of serum lipids, glucose, Total Cholesterol, HDL, LDL and Triglycerides. The lessThan i greaterThan A. heterophyllum lessThan /i greaterThan treatment markedly lowered total cholesterol, triglycerides in blood serum. It also showed positive effects (increase) on serum high-density lipoprotein cholesterol (HDL-c) concentrations. Presence of flavonoids, alkaloids, tannins and steroids may be responsible for its antiobesity activity. The results demonstrated that feeding with High Fatty Diet had caused a significant increase in weight gain compared with the zero-day activity, which was significantly decreased by the co-administration of lessThan i greaterThan A. Heterophyllum lessThan /i greaterThan especially Alcoholic Extract of lessThan i greaterThan A. Heterophyllum lessThan /i greaterThan e (AAH) in a dose-dependent manner. Thus the present findings emphasize that the roots of lessThan i greaterThan A. Heterophyllum lessThan /i greaterThan possesses potential medicinal values. JAIN SURENDRA KUMAR, JAIN RUCHI AND JAIN NILESH Aconitum Heterophyllum, Antiobesity, Cholesterol, Ayurveda, Herbal 65-74