10.22376/ijpbs.2019.10.1.p1-12 Volume 10 Issue 4 2019 (October-December) This study evaluates the anti-bacterial potential of lessThan i greaterThan M. indica lessThan /i greaterThan twig and kernel phytochemicals against the common oral bacterial pathogens including lessThan i greaterThan S. aureus, St. oralis, St. mutans, St. gordonii, L. brevis lessThan /i greaterThan and lessThan i greaterThan L. casei lessThan /i greaterThan . The twig and kernel dried powder samples were fractionated with Soxhlet extractor with eluotrophic series of solvents viz. petroleum-ether, chloroform, absolute-ethanol, 80%-methanol and distilled-water. Antibacterial activity of the fractionated extracts was determined by zone of inhibition, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and 50% inhibitory concentration (IC lessThan sub greaterThan 50 lessThan /sub greaterThan ) values against oral pathogens while antioxidant activity was measured by ABTS lessThan sup greaterThan + lessThan /sup greaterThan and DPPH assays. The results showed exceptionally high antibacterial activity in kernel ethanolic extracts (MiKE) against all the tested oral bacterial pathogens as confirmed by its highest zone of inhibition and lowest MIC, MBC and IC50 values. lessThan i greaterThan M.indica lessThan /i greaterThan kernel extracts (MiKE) was extremely effective against lessThan i greaterThan S. aureus lessThan /i greaterThan followed by lessThan i greaterThan St. oralis, St. gordonii, L. brevis, St. mutans, lessThan /i greaterThan and lessThan i greaterThan L. casei lessThan /i greaterThan with the IC lessThan sub greaterThan 50 lessThan /sub greaterThan value of 0.015, 0.027, 0.056, 0.081, 0.108±0.003 and 0.122±0.001 mg/ml respectively. MiKE showed excellent ABTS lessThan sup greaterThan + lessThan /sup greaterThan and DPPH free radical scavenging activities with IC lessThan sub greaterThan 50 lessThan /sub greaterThan values of 0.649±0.0 and 0.264±0.001 µg/ml respectively amid abundance of phenolics, flavanoids and tannins. Regression analysis of antibacterial activities of fractionated extracts with phytochemical contents and antioxidant activities suggested existence of multiple pathways of inhibition in bacteria. Present study successfully establishes lessThan i greaterThan M. indica lessThan /i greaterThan kernel extracts as an incredible and safe prospective natural remedy for oral-dental infection. SAVITA PETWAL, MADHURI KAUSHISH LILY, HIMANI SINGH AND KOUSHALYA DANGWAL Antibacterial activity; antioxidant; M.indica kernel; oral bacterial pathogens; polyphenols 112-123