10.22376/ijpbs.2019.10.1.p1-12 Volume 11 Issue 4 2020 (October-December) A novel coronavirus (SARS-CoV-2) originated from the Human Seafood Market in Wuhan, China. World Health Organization named it as COVID-19 which spread quickly all over the country and the world. The sources and the pathogenesis characteristics of this virus are still unidentified. In the meantime, many independent researcher groups have identified that the SARS-CoV-2 belongs to β-coronavirus with identical genome sequence to bat coronavirus, and pointing out that bat is the natural host. The COVID-19 utilizes the similar receptor angiotensin converting enzyme-2 (ACE-2) as like SARS-CoV and commonly spreads via the respiratory tract infection. The clinical sign and symptoms of COVID-19 include cough, fever, fatigue, headache and breathing problem. The elderly patients and people with underlying disorders are more susceptible to infection and prone to serious effects which may be associated with some of the acute respiratory distress syndrome. There is no specific treatment such as vaccination and therapeutic drug molecule has not been found. Currently, some antiviral drugs are in used for the treatment of coronavirus but they are not that much effective. In this review article, we focus on the general overview and pathogenesis characteristics of COVID-19. In this we have discussed the various vaccination strategies, use of traditional medicine system and convalescent plasma therapy for the treatment of coronavirus. Also we highlight the break chain theory which helps to avoid the transmission of virus from one human body to another. The worldwide impact of this epidemic is still undetermined.  Priya Dhiman*, Anurag Kumar Dhiman COVID-19, SARS-CoV-2, SARS CoV, MERS CoV, clinical symptoms, break chain theory. 99-108