10.22376/ijpbs.2019.10.1.p1-12 Volume 15 Issue 1 January - March Hypotension is the primary adverse outcome associated with spinal anesthesia during cesarean delivery, potentially leading to adverse effectsin mothers and acid-base imbalances in newborns. It is widely acknowledged that efficient intervention is crucial to prevent any negative impact on fetalbirth. Administering anesthesia to pregnant women requires the highest level of care, as the anesthesiologist must consider the well-being of both themother and the fetus. The primary side effect of spinal anesthesia during a cesarean birth, which could lead to unfavorable symptoms in the mother andacid-base consequences in the newborn, is hypotension. Phenylephrine and ephedrine are known for their efficacy in preventing hypotension followingspinal anesthesia. This study aims to assess the effectiveness of prophylactic infusions of phenylephrine and ephedrine in averting hypotension duringelective lower-segment cesarean sections under spinal anesthesia. Examining the impact of prophylactic infusions of phenylephrine and ephedrine asvasopressors. Treatments during Unconsciousness originating in the spinal cord for cesarean sections and their impact on infant outcomes wereinvestigated. We found that both Ephedrine and phenylephrine effectively managed systolic, diastolic, and mean arterial pressure. The ephedrine groupneeded a significantly higher number of additional boluses than the phenylephrine group (p value lessThan 0.001). The phenylephrine group exhibited a morefavorable pH and lower acidosis levels than the ephedrine group (p-value 0.05). Prophylactic administration of phenylephrine at a dosage of 15 mcg/minproved more effective in sustaining arterial blood pressure following spinal anesthesia for cesarean delivery than Ephedrine at 1.5 mg/min, and this effectedreduced acidosis in newborns. Harekrishna Ray, Madhumita Biswal, Basanta Kumar Pradhan, Sujata Mishra and Mangal Charan Murmu Acidemia, Spinal anesthesia, Phenylephrine, Ephedrine, Hypotension, and Caesarean Section. 49-56