10.22376/ijpbs.2019.10.1.p1-12 Volume 15 Issue 1 January - March Artesunate is a natural product in Artemisia apiacea, Acronychiapubescens, and Artemisia carvifolia. It is indicated forthe initial treatment of severe malaria. The World Health Organization recommends Artesunate as a first-line treatment formalaria. The main aim of our study was to develop and validate a simple, accurate, cost-effective UV- VisibleSpectrophotometric method for estimating Artesunate in bulk and pharmaceutical dosage forms. Degradation studies forArtesunate using the UV Spectroscopic method currently not available. The study has extended towards investigating stressdegradation behavior by exposing it to various forced degradation conditions. A solvent was used to develop a method ofArtesunate, methanol, and water in the ratio of 1:9. The λmax was found to be at 248nm. The linearity range was fixed as 10μg/ml-50μg/ml with an R2 of 0.9997. The % recovery was 98-102%, indicating the method's accuracy. The developed method isvalidated as per ICH Q2 guidelines. The LOD and LOQ were 0.435μg/ml and 1.31μg/ml respectively. The % RSD was found tobe well within the limits. The drug showed less stability in oxidative and thermal conditions. Gangu Sreelatha, J.S Swatantra, E. Ratna Sri, Ch. Samatha and G. BhagyaLaxmi Artesunate, Stability, Validation, ICH Guidelines, UV- Visible Spectrophotometry, Degradation. 57-63