10.22376/ijpbs.2019.10.1.p1-12 Volume 15 Issue 1 January - March Chronic Kidney Disease (CKD) is a progressive loss in renal function over 3 months of a year. CKD adversely affects thehaematopoietic system, the most common clinical manifestation being anaemia, which contributes to the morbidity and mortality ofthe condition. Hemoglobin levels measured after hemodialysis, compared to those measured before hemodialysis, are suggested tobe a more accurate reflection of the hemoglobin levels between hemodialysis sessions and a better reference point for adjustingerythropoietin dosing. Anaemia may be predictive of an increased risk of mortality in HD patients. The study compared varioushaemoglobin before and after haemodialysis in chronic kidney disease patients in Tertiary Care Hospital. The present observationalstudy was carried out among 55 CKD patients admitted to the hospital for hemodialysis during the study period. Patients withhaematological malignancies, bleeding disorders, and unwillingness to participate were excluded. The collected data were analysedwith proper statistical methods. Out of 55 CKD patients, 43 were men, and 12 were women, with a mean age of 53.20 13.24 years.51 to 70 years old comprised most of our study's age group. Pre-HD and post-HD hemoglobin levels had a p-value of 0.017. Afterhemodialysis, the hemoglobin levels in post-HD patients fell with a statistically significant difference. (p lessThan 0.05). Monitoring hemoglobinlevels before and following hemodialysis may aid in avoiding any potential anaemia-related problems, lowering mortality andmorbidity. Although the current study has limitations, additional research is advised for definitive conclusions. Dr. Sameer Kadam, Dr. Vaishali Bhonsale, Dr.Gargi Patil, Dr. Vijay Dombale, Dr. R Deshpande and Miss. Akshata Kelkar Hemoglobin, Chronic Kidney Disease, Hemodialysis, End Stage Renal Disease, Renal Function 23-28