10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 2 2011 (April - June) On the basis of a large number of solubilization experiments on poorly water-soluble drugs, the author is of the opinion that hydrotropy is another type of co-solvency and all water soluble substances whether liquids or solids may act as solubilizers for poorly water-soluble drugs. In the present investigation, mixed-solvency concept has been utilized for solubility enhancement of poorly water-soluble drug, gatifloxacin. One blend containing mixed solvent system of sodium citrate, sodium benzoate, glycerin and PEG-4000 (ten percent each) was made to study the influence on solubility of gatifloxacin. The blend was found to increase the solubility of gatifloxacin synergistically. This concept shall prove a boon in pharmaceutical field (and also in non-pharmaceutical field viz. chemical engineering etc.). In the present investigation, the mixed-solvency concept has been employed to analyze gatifloxacin in the bulk drug sample precluding the use of organic solvents (a way towards green chemistry). Neha Bhawsar, Rajesh Kumar Maheshwari, Aasif Ansari And Yashwardhan Saktawat Gatifloxacin, Mixed solvency, Solubility enhancement, UV-Visible Spectrophotometry. 270-274