International Journal of Pharma and Bio Sciences
ijpbs.net
editorijpbs@rediffmail.com (or) editorofijpbs@yahoo.com (or) prasmol@rediffmail.com
10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 2
2011 (April - June)
Ameliorative Action Of Nigella Sativa Against Iron Induced Chromosomal Aberrations In Rat Bone Marrow Cells In Vivo
Iron deficiency is a worldwide problem and is, in general, more frequent than its excess. lessThan i greaterThan Nigella sativa lessThan /i greaterThan may also act as an ROS scavenger and as a metal chelant. To examine these possibilities, we tested lessThan i greaterThan in vivo lessThan /i greaterThan the effect of lessThan i greaterThan Nigella sativa lessThan /i greaterThan (50 mg/kg b.wt.) against the genotoxicity of FeSO lessThan sub greaterThan 4. lessThan /sub greaterThan 7H lessThan sub greaterThan 2 lessThan /sub greaterThan O. Bone marrow cells were obtained from the rats using the technique described by Preston lessThan i greaterThan et al lessThan /i greaterThan . (1987). The results of treatments with lessThan i greaterThan Nigella sativa lessThan /i greaterThan indicated that it statistically significantly decreases the number of with aberrations induced by FeSO lessThan sub greaterThan 4. lessThan /sub greaterThan 7H lessThan sub greaterThan 2 lessThan /sub greaterThan O, but it cannot completely protect cells from damage. lessThan i greaterThan Nigella sativa lessThan /i greaterThan showed the most efficient anticlastogenic effect during simultaneous treatment with FeSO lessThan sub greaterThan 4. lessThan /sub greaterThan 7H lessThan sub greaterThan 2 lessThan /sub greaterThan O. The result further strengthened the findings about the protective and antigenotoxic properties of lessThan i greaterThan Nigella sativa lessThan /i greaterThan .
Nuzhat Parveen And G. G. H. A. Shadab
Nigella sativa; Chromosomal aberrations; Ferrous sulfate; Genotoxicity.
470-477