10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 3 2011 (July - September) The present review deals with treatment to various disorders with normal body rhythms like Ultradian, Circadian, Infradian & Seasonal. The basics of Chronotherapy and its advantages and disadvantages following the marketed technologies for the drug-chronotherapy are focused. The rational therapy to various diseases like: Hypertension, Bronchial asthma, Peptic ulcers, Myocardial infarction, Arthritis, Cerebrovascular accidents & Hypercholesterolemia by Chronotherapy is also enlightened. The regulatory concern on Chrono-Pharmaceuticals is glanced. P. Srinivas ,G. Sandeep, A. Rohan Pridhvi And Y. Soujanya ChronoPharmaceuticals, Bio-rhythms, Chronotherapy & Chronotherapeutics. 19-23