10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 3 2011 (July - September) The present study was designed to investigate anti-inflammatory activity of Petroleum ether and Methanolic extract of lessThan i greaterThan Benincasa hispida lessThan /i greaterThan fruit. Both the extracts at the dose of 300 mg/kg body weight, produced dose dependent and significant inhibition of carrageenan- induced paw edema, histamine induced paw edema and cotton pellet- induced granuloma in rat model. In carrageenan- induced paw edema model, petroleum ether and methanolic extracts showed maximum inhibition in inflammation (0.270 ± 0.063, 0.307 ± 0.043 respectively) as compared to control group (1.27 ± 0.059) which were comparable with standard valdecoxib (0.247 ± 0.033). In histamine-induced paw edema, both the extract showed maximum inhibition (62.86% and 54.84% respectively) as compared to control group, which were comparable with that of standard drug cetrizine (95.24%). Petroleum ether and methanolic extracts showed slight reduction in granuloma tissue formation in cotton pellet implanted rats, which were not significant with that of standard drug diclofenac sodium. Ma Rachchh, Pn Yadav, Rh Gokani and Jain Benincasa hispida, carrageenan- induced paw edema, histamine-induced paw edema, cotton pellet- induced granuloma 98-106