10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 3 2011 (July - September) A series of 2-aminomethylene-[2´-(3´´-chloro-2´´-oxo-4´´-substitutedaryl-1´´-azetidinyl)-1´,3´,4´-thiadiazol-5´-yl)pyridines (5a-5g) and 2-aminomethylene-[2´-(2´´-substitutedaryl-4´´-thiazolidinone-3´´-yl)-1´,3´,4´-thiadiazol-5´-yl]pyridines (6a-6g) has been synthesised from 2-aminomethylene-(2´-substitutedarylidineimino-1´,3´,4´-thiadiazol-5´-yl)pyridines (4a-4g). The structures of all these compounds were established on the basis of elemental (C,H,N) and spectral (IR, lessThan sup greaterThan 1 lessThan /sup greaterThan H-NMR and mass spectral data) analysis. All the compounds were screened for their antifungal activity. Compound 2-aminomethyene-[2´-(2´´-(3-hydroxyphenyl)-4´´-thiazolidinone-3´´-yl)-1´,3´,4´-thiadiazol-5´-yl]pyridines were found to be the most potent compound of the series and its activity was compared with the reference drugs Fluconazole and Gieseofulvin. Chatrasal Singh Rajput, Sanjeev Sharma# And Yashovardhan Pyridine, thiadiazole, thiazolidinone, azetidinone and antifungal activity. 200-209