10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 3 2011 (July - September) Three simple and sensitive Spectrophotometric methods (A, B & C) have been developed for the estimation of Entecavir (ETV) in pure and pharmaceutical dosage forms. Method A is based on the formation of colored species by redox reaction with Folin-Ciocalteau (FC) phenol's reagent under alkaline conditions (λmax: 750 nm). Method B is based on oxidative coupling of the drug with 3-methyl-2-benzothiazolinone hydrazone HCL (MBTH) in the presence of ferric chloride (λmax: 650 nm).Method c is based on formation of Schiff's base by the condensation of drug with p-dimethyl amino benzaldehyde (PDAB) under acidic conditions (λmax: 430 nm). These methods have been statistically evaluated and found to be precise and accurate. M. Rajeswari, P. Subrahmanyam, G. Devala Rao G. Sudhakar Sai Babu Entecavir and Spectrophotometry. 210-213