10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 3 2011 (July - September) The Poly herbal ethanolic extract (PHEE) was evaluated for its anti hepatotoxic potential against carbon tetrachloride (CCL lessThan sub greaterThan 4 lessThan /sub greaterThan ) induced hepatic damage in male albino rats. Ethanolic extract from the leaves of Melia azadirachta, seeds of Piper longum and whole plant of Eclipta alba at a dose level of 50 mg/kg body weight was administered orally daily once for 14 days. The substantially reduced levels of enzymatic anti-oxidants such as superoxide dismutase(SOD), catalase(CAT), glutathione peroxidase (GPx), glutathione-s-transferase(GST) and glutathione reductase (GR), due to carbon tetra chloride effect were restored to normal. Histopathological examination of liver sections of PHEE treated rats shows the restoration of normal tissues. Vitamin-E at a dose of 100 mg/kg taken as a standard reference also exhibited significant antioxidant activity against CCl lessThan sub greaterThan 4 lessThan /sub greaterThan induced Hepatotoxicity. The results of this study strongly justified that PHEE has a potent hepatoprotective activity against carbon tetrachloride Kavitha.M, Karimulla.Sk, Deepak Kumar, Vinoth Kumar.S Polyherbal ethanolic extract, Anti hepatotoxic potential, Carbon tetrachloride, Lipid peroxidation, Antioxidant enzymes. 307-312