10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 3 2011 (July - September) Ethanol extract of lessThan i greaterThan Cassia sophera lessThan /i greaterThan (Caesalpiniaceae) was evaluated for hepatoprotective activity in rats. The plant extract (500 mg/kg, p.o.) showed a remarkable hepatoprotective activity against paracetamol induced hepatotoxicity as judged from the serum markers for liver damage. Paracetamol induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin and decrease in total protein. Treatment of rats with ethanol extract (500 mg/kg) significantly altered serum marker enzymes levels to near normal against paracetamol treated rats. The activity of the extract was comparable to the standard drug Liv-52 (5 ml/kg, p.o.) Histopathological changes of liver sample were compared with respective control. Results indicate that lessThan i greaterThan Cassia sophera lessThan /i greaterThan possesses hepatoprotective effect on paracetamol induced hepatotoxicity in rats. Wankhade P.W, Nagore D. H, Kotagale N. R, Turaskar A. O and More S. M Cassia sophera, Paracetamol, biochemical parameters and hepatotoxicity. 433-438