International Journal of Pharma and Bio Sciences
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10.22376/ijpbs.2019.10.1.p1-12
Volume 2 Issue 3
2011 (July - September)
Altered Expression Of Pedilanthus Tithymaloidus Lectin Binding Glycoprotein On Erythrocytes In Thyroid Disorders, A Preliminary Report
Measurable morphological changes in plasma and cell membrane glycoprotein are noted in various diseases. Lectin mediated agglutination of red blood cell can reveal such alteration. Present investigation was undertaken to assess the binding characteristics of lessThan i greaterThan P. tithymaloidus agglutinin lessThan /i greaterThan on erythrocytes from thyroid disorders to find any alteration in membrane glycoproteins. In our study, hyperthyroidism has shown significantly increased hemagglutination titer (82.3 ± 52.9), where as decreased hemagglutination titer has been observed in hypothyroidism (34.1 ± 23.1). Observed finding substantiate that thyroid induced metabolic stress bring change in membrane glycoproteins which is reflected in the form of altered lectin binding activity on erythrocyte.
Dhiraj J. Trivedi, Chhaya D Trivedi And Anil Bargale
Lectin, Hemagglutinin, Erythrocyte, Thyroid
411-415