10.22376/ijpbs.2019.10.1.p1-12 Volume 2 Issue 4 2011 (October - December) β-lactam antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contain a β-lactam nucleus in its molecular structure. Till now β-lactams like penicillins, cephalosporins, monobactams, and carbapenems have been developed. Resistance to various β-lactam antibiotics among target pathogens were started with its first use.The most widespread and important cause is the destruction of the β-lactam ring, mediated by β-lactamases. Antibiotic resistance can be overcome successfully with the use of β-lactamase inhibitors in combination with β-lactams. Resistance within a few years of the introduction of the antibiotic class seems inevitable that the new antibiotics developed to hit novel targets will also encounter resistance. Hence, it's needed to identify novel therapeutics to be used as β-lactamase inhibitors. Present study was accomplished to develop novel β-lactamase inhibitors and their comparative study with the already present ones. Most promising results were shown by phenolic derivatives of sulbactam. Deepak Kumar Jha, Likunpanda And Anand Anbarasu β-lactamases, NDM1, Sulbactam, Molecular docking, ACE Values 88-98